Researchers at Georgia State University have released a study that shows how pain in infancy alters the brain’s ability to process pain in adulthood.
The study indicates that infants who spent time in the neonatal intensive care unit (NICU) show altered pain sensitivity in adolescence. These results have profound implications, and highlight the need for pre-emptive and post-operative pain medicine for newborn infants.
The study shows how the mechanisims of pain are altered after infant injury in a region of the brain called the periaqueductal gray. For the study, rats were used to examine why the brief experience of pain at the time of birth permanently decreased painsensitivity in adulthood.
Endogenous opioidpeptides serve to inhibit pain and are also the “feel good” substances that are released following high levels of exercise or love. These peptides are also released following injury and act like morphine to dampen the experience ofpain.
The researchers observed that adult animals that were injured at the time of birth had endogenous opioidlevels that were twice as high as normal. They also found a large decrease in the availability of mu and delta opioid receptors, which are necessary in order for pain medications to work.
This means that it takes more pain-relieving medications in order to provide relief. Studies in humans found similar results.
If your child has suffered a birth related injuries, please contact the Philadelphia Birth Injury Lawyers of Lowenthal & Abrams, P.C., at 215-329-3511.


